Cirsium vulgare (Savi) Ten. (Spear Thistle): Plant characteristics, phytochemistry, and pharmacological properties
Farzana Yasmin
Abstract
Since prehistoric times, man and his quest for drugs in the natural world have been linked. All societies have used plants for medicinal purposes. Plants are used as medicines, cosmetics, pharmaceuticals, and food supplements - Cirsium vulgare (Savi) Ten. (Bull thistle or spear thistle) is a traditionally significant plant used to treat various diseases. In addition to medicinal qualities, Cirsium vulgare can be utilized as survival food if necessary. It possesses several medicinal properties, including antibacterial, anticancer, antioxidant, anti-fungal, anti-inflammatory, anti-hemorrhoidal, and hepatoprotective effects. It is abundant with phytochemicals such as phenolic acids, flavonoids, terpenoids, esters, tannins, glycosides, and apigenin. The current article aims to emphasize the taxonomy, morphology, phytoconstituents, geographic distribution, and pharmacological effects of Cirsium vulgare that have been previously documented.
Keywords
References
- Obel MA, Asfoor TAT. The potential of endemic medicinal plants in the central regions of Abyan Governorate, Yemen for sustainable pharmaceutical applications. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 2025; 5(3): 46-51. doi: 10.5281/zenodo.16537815
- Iyekowa I, Oderanti AO. Chemical analysis and analgesic activity of methanol extract of Crinium Jagus bulb in BALB/c mice. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 2023; 3(1): 19-25. doi: 10.5281/ zenodo.7771339
- Shahrajabian MH. Spear thistle (Cirsium vulgare L.) and ramsons (Allium ursinum L.), impressive health benefits and high-nutrient medicinal plants. Pharmacognosy Communications. 2021; 11(3): 168-171. doi: 10.5530/pc.2021. 3.32
- Zheng F, Zhan C, Yang K, Li Q, Wang Z, Xu G, et al. Allelopathic Potential of Newly Emerged Invasive Plant Cirsium vulgare (Asteraceae) in Yunnan Province of China. Plants. 2026; 15(3): 513. doi: 10.3390/plants15030513
- Luo W, Wu B, Tang L, Li G, Chen H, Yin X. Recent research progress of Cirsium medicinal plants in China. Journal of Ethnopharmacology. 2021; 280: 114475. doi: 10.1016/j.jep.2021.114475
- Aggarwal G, Kaur G, Bhardwaj G, Mutreja V, Sohal HS, Nayik GA, et al. Traditional uses, phytochemical composition, pharmacological properties, and the biodiscovery potential of the genus Cirsium. Chemistry. 2022; 4(4): 1161-1192. doi: 10.3390/chemistry4040079
- Aydın Kurç M, Orak HH, Gülen D, Caliskan H, Argon M, Sabudak T. Antimicrobial and antioxidant efficacy of the lipophilic extract of Cirsium vulgare. Molecules. 2023; 28(20): 7177. doi: 10.3390/molecules28207177
- Griškevičienė U, Marksa M, Ževžikovienė A, Kazlauskienė D, Vainorienė R, Ževžikovas A, Ivanauskas L. Cirsium vulgare leaves: Isolation and identification of phenolic compounds. Chemija. 2021; 32(3-4): 92-99. doi: Nil.
- Nazaruk J, Chłędzik S, Strawa J, Bazydło K, Wajs-Bonikowska A. Chemical composition and antioxidant activity of Cirsium vulgare inflorescences. Natural Product Communications. 2017; 12(4): 519-522. doi: 1934578X 1701200414
- Zheng F, Zhan C, Yang K, Li Q, Wang Z, Xu G, et al. Allelopathic potential of newly emerged invasive plant Cirsium vulgare (Asteraceae) in Yunnan Province of China. Plants. 2026;15(3): 513. doi: 10.3390/plants15030513
- Griškevičienė U, Ivanauskas L, Petrikaitė V. Anticancer properties of Cirsium vulgare (Savi) ten. Dry extracts from different plant parts and phenological stages of raw material collection. Scientific Reports. 2025; 15(1): 12105. doi: 10.1038/s41598-025-96329-4
- Sabudak T, Orak HH, Gulen D, Ozer M, Caliskan H, Bahrisefit I, Cabi E. Investigation of some antibacterial and antioxidant properties of wild Cirsium vulgare from Turkey. Indian Journal of Pharmaceutical Education and Research. 2017; 51(3s2): e363-s367. doi: 10.5530/iiper.51.3s.48
- Griskeviciene U, Dambrauskiene J, Marksa M, Mazeliene Z, Vainoriene R, Ivanauskas L. Effect of the phenological stage on the phenolic composition, and antioxidant and antimicrobial properties of Cirsium vulgare (Savi) Ten. Extracts. Life. 2024; 14(9): 1191. doi: 10.3390/life14091191
- Han KSS, Win KT, Chit MT. Evaluation of antimicrobial, antioxidant, antidiabetic activities, and acute toxicity of Elephantopus scaber L. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 2025; 5(2): 87-95. doi: 10.5281/zenodo.15365040
- Basatinya AM, Sajedianfard J, Nazifi S, Hosseinzadeh S, Kamrani Mehni M, et al. Effects of ethanolic extracts of Quercus, Cirsium vulgare, and Falcaria vulgaris on gastric ulcer, antioxidant and inflammatory indices, and gene expression in rats. Physiological Reports. 2021; 9(16): e14954. doi: 10.14814/phy2.14954
- Moreno LYZ, Medrano MIS, Zeron HM. Action of Regenerator Cel gel (acetyl dressing/antiseptic) and Remotis solution (acetyl dressing/antiseptic) in the treatment of wounds. Mediterranean Journal of Medicine and Medical Sciences. 2026; 2(1): 59-65. doi: 10.5281/zenodo.18987510
- Kilani MA, Oladimeji LO, Oyenekan IO, Binhambali A, Audu HA, Obalowu AM, et al. Significance of Croton lobatus L. leaf extract on the healing of surgically created wounds in laboratory rats. Mediterranean Journal of Pharmacy and Pharmaceutical Sciences. 2025; 5(2): 141-151. doi: 10.5281/zenodo.15741778
- Nisa ZU, Sabir SM, Ahmad Z, Ullah I, Akhlaq M. Analysis of hepatoprotective and antioxidant activities, and determination of the phenolic profile of Moringa oleifera. Mediterranean Journal of Medical Research. 2026; 3(1): 86-93. doi: 10.5281/zenodo.18912004
- Moukhtar KM, Douma AD. Urtica diocia L. ameliorative efficiency against CCl4-induced hepatic fibrosis in rats. Mediterranean Journal of Medical Research. 2026; 3(1): 1-13. doi: 10.5281/zenodo.18120112
Submitted date:
04/27/2026
Reviewed date:
06/06/2026
Accepted date:
06/13/2026
Publication date:
06/13/2026
